Fonction
Directeur de recherches au CNRS, Université de Reims Champagne-Ardenne
Coordonnées
Institut de Chimie Moléculaire de Reims (ICMR)
UFR des Sciences Exactes et Naturelles BP 1039 51687 REIMS Cedex 2 – France
Tél : +33 (0)3 26 91 82 10
Mèl : jm.nuzillard@univ-reims.fr
Activités de recherche
Analyse structurale des petites molécules organiques par Résonance Magnétique Nucléaire
Mots clés
Résonance Magnétique Nucléaire expérimentale ; traitement du signal ; intelligence artificielle ; substances naturelles
Publications récentes
Wenk M., Nuzillard J.-M., Steinbeck C.
Sherlock—A Free and Open-Source System for the Computer-Assisted Structure Elucidation of Organic Compounds from NMR Data.
Molecules 2023, 28, 1448. DOI : 10.3390/molecules28031448. hal-03972070
Nuzillard J.-M.
Easy Structural Dereplication of Natural Products by Means of Predicted Carbon-13 Nuclear Nuzillard J.-M., S. Kuhn
Chem.: Methods 2022, e202200054. DOI : 10.1002/cmtd.202200054. hal-03868855
Pedinielli F., Leroy R., Martinez A., Nuzillard J.-M., Lameiras P.
ViscY NMR experiments in phosphoric acid as a viscous solvent for individualization of small molecules within mixtures by spin diffusion.
Analyst 2021, 146, 5316–5325. DOI: 10.1039/d1an00899d. hal-03331622
Charlier C., Cox N., Prud'homme S. M., Geffard A., Nuzillard J.-M., Luy B., Lippens G.
Virtual decoupling to break the Simplification Versus Resolution Trade Off in NMR of Complex Metabolic Mixtures.
Magn. Reson. 2021, 2, 619-627. DOI: 10.5194/mr-2-619-2021. hal-03338624
Nuzillard J.-M.
Taxonomy-Focused Natural Product Databases for Carbon-13 NMR-Based Dereplication.
Analytica 2021, 2, 50–56. DOI: 10.3390/analytica2030006. hal-03338621
Bruguière A., Derbré S., Bréard D., Tomi F., Nuzillard J.-M., Richomme P.
13C NMR dereplication using MixONat software: a practical guide to decipher natural products mixtures.
Planta Med. 2021, 87, 1061-1068. DOI: 10.1055/a-1470-0446. hal-03220850
Kuhn S., Schlörer N. E., Jeannerat D., Erdelyi M., Wieske H., Schober D., Nuzillard J.-M., Junker J.
NMReDATA: Tools and applications.
Magn. Reson. Chem. 2021, 59, 792-803. DOI: 10.1002/mrc.5146. hal-03191016
Lianza M., Leroy R., Machado Rodrigues C., Borie N., Sayagh C., Remy S., Kuhn S., Renault J.-H., Nuzillard J.-M.
The three pillars of natural product dereplication. Alkaloids from the bulbs of Urceolina peruviana (C. Presl) J.F. Macbr. as a preliminary test case.
Molecules 2021, 26, 637. DOI: 10.3390/molecules26030637. hal-03126780
Wolfender J.-L., Nuzillard J.-M., van der Hooft J. J. J., Renault J.-H., Bertrand S.
"Accelerating Metabolite Identification in Natural Product Research: Toward an Ideal Combination of Liquid Chromatography−High-Resolution Tandem Mass Spectrometry and NMR Profiling, in Silico Databases, and Chemometrics."
Anal. Chem. 2019, 91, 704−742. DOI: 10.1021/acs.analchem.8b05112
Ibrahim N., Allart-Simon I., De Nicola G. R., Iori R., Renault, J.-H. Rollin P., Nuzillard J.-M.
"An Advanced NMR-based Structural Investigation of Glucosinolates and Desulfoglucosinolates."
J. Nat. Prod. 2018, 81, 323–334. DOI: 10.1021/acs.jnatprod.7b00776
Nuzillard J.-M., Plainchont B.
"Tutorial for the structure elucidation of small molecules by means of the LSD software."
Magn. Res. Chem. 2018, 56, 458–468. DOI: 10.1002/mrc.4612
Bakiri A., Plainchont B., Emerenciano V. de P., Reynaud R., Hubert J., Renault J.-H., Nuzillard J.-M.
"Computer-aided Dereplication and Structure Elucidation of Natural Products at the University of Reims."
Mol. Inf. 2017, 36, 1700027. DOI: 10.1002/minf.201700027
Lameiras P., Patis S., Jakhlal J., Castex S., Clivio P., Nuzillard J.-M.
"Small molecule mixture analysis by heteronuclear NMR under spin diffusion conditions in the viscous DMSO-water solvent."
Chem. Eur. J. 2017, 23, 4923–4929. DOI: 10.1002/chem.201700636.
Prix, récompenses
Médaille de bronze du CNRS