Home
Presentation
The CardioVir team (EA-4684) is located at the Faculty of Medicine of Reims. It gathers medical hospital and university-hospital specialists in medical virology, anatomopathology, cardiology and infectious diseases of the University Hospital of Reims as well as young researchers (post-doctoral and doctoral students) supported by a researcher, a research technician and a common secretariat. The team "Viral cardiovascular infections and inflammation in human pathology" studies the viral and immunological mechanisms involved in acute and persistent viral cardiac infections by enteroviruses (EVs), naked RNA+ viruses (Picornaviridae) and their role in the development of unexplained cardiac pathologies such as dilated cardiomyopathy (DCM), which is the second most common cause of cardiac transplantation in the world. Between 2016 and 2020, the team identified by Next Generation Sequencing (NGS) the existence of natural viral deletions modifying the secondary structural elements of the domain-1 (Cloverleaf) of the 5' RNA region of EVs that are specifically recognized by innate cellular immunity sensors, in particular the RIG-I and MDA5 receptors (RLR).
EA 4684 - Viral cardiovascular infections and inflammation in human pathology
Head of the department
Laurent ANDREOLETTI
MD-PhD
Tel : +33 3 26 91 81 17
Fax : +33 3 26 91 31 43
landreoletti@chu-reims.fr