Presentation of the CardioVir UMR-S 1320

The CardioVir team (UMR-S 1320) "Viral cardiovascular infections and inflammation in human pathology" is located at the Faculty of Medicine of Reims. It gathers medical hospital and university-hospital specialists in medical virology, anatomopathology, cardiology and infectious diseases of the University Hospital of Reims as well as young researchers (post-doctoral and doctoral students) supported by a researcher, a research technician and a common secretariat. 

The aim of UMR-S 1320 CardioVir research group  (Medicine Faculty of Reims, France) is to study the viral and immunological mechanisms involved in cardiovascular infections caused by single-stranded (+) RNA viruses, including group B enteroviruses (EV-B), SARS-CoV-2 and emerging or re-emerging viruses such as dengue or Zika viruses. Recently, our research group used NGS and experimental molecular approaches (primary human cells and mouse models (WT or KO) to identify the pathophysiological role of novel virus forms that are truncated in the 5'NC region (domain I of viral genomic RNA) and modulate the innate immune response via RLR receptors (RIG-I and MDA5) during acute and chronic myocarditis caused by enterovirus group B (EV-B) in humans and mouse models.

In addition, our recent research goals focus on gaining a comprehensive understanding of how viral genomic RNA epitranscriptomics in human cardiomyocytes would allow the virus to overcome host cellular RNA recognition mechanisms, in particular the type I interferon response.

In summary, our research is based on the ability of naturally modified single-stranded (+) RNA viral forms (truncated or with epitranscriptomic modifications) to modulate the innate immune as well inflammatory responses in various human target cells, particularly during the pathophysiologic course of human cardiovascular viral infections.

Head of the department

Laurent ANDREOLETTI
University Professor - Hospital Practitioner
Tel: +33 3 26 91 81 17
Fax: +33 3 26 91 31 43
E-mail: landreoletti@chu-reims.fr

Laboratory address

University of Reims Champagne Ardenne
Faculty of Medicine, Building A, 3rd floor
Laboratory of Medical and Molecular Virology 
INSERM UMR-S 1320
51 rue Cognacq Jay
51100 Reims Cedex France

Keywords

Enterovirus, Molécular virology, Myocarditis, Sudden cardiac death, Viral recombination, Innate immunity