Presentation of the unit

Version française

Created in 2004 by the University of Reims Champagne-Ardenne (URCA) by academic cardiologists and pharmacologists (Dir. Prof. Elaerts, then Prof. Millart), the EA 3801 (myocardial pre-conditioning) was restructured in 2008, by hosting hemostasis specialized academic researchers and physicians (Dir. Prof. Philippe Nguyen). In 2012, EA 3801 HERVI has been certified by the University of Reims Champagne-Ardenne.

The unit is located in the research building of the medical faculty of Reims (URCA) and the laboratory of hematology of the Academic Hospital (CHU) of Reims.

The EA 3801 HERVI unit studies the mechanisms of haemostasis involved during ischemia and reperfusion phenomena. The team is more specifically interested in the regulation of tissue factor expression by blood and endothelial cells: role of microenvironment and inflammation. It develops experimental models for the analysis of mechanisms involved in ischemia (pre- and post-myocardial conditioning, critical ischemia of the lower limbs). The laboratory is very involved in clinical work, supported by fundamental projects.

Collaborations

Scientific partnership:

  • INSERM U1096 EnVI : Endothelium, Valvulopathy & Heart Failure, Rouen.
  • UMR CNRS/URCA 7369 : Matrice extracellulaire et dynamique cellulaire, Reims.
  • UMR S1076 INSERM : Physiopathologie de l'endothélium, Marseille.
  • UMR S1140 INSERM : Innovation Thérapeutique en Hémostase, Paris V.
  • INSERM U1059 : Dysfonctionnement Vasculaire de l'Hémostase, Saint-Etienne.
  • EA 3860 : Cardioprotection, remodelage et thrombose, Université d'Angers.
  • INSERM U1082 : Ischémie, Reperfusion et Transplantation d'organes - Mécanismes et Innovations Thérapeutiques, Poitiers.
  • UMS2008 : Ingénierie Biologie Santé en Lorraine
  • CNRS UMR 7312 ICMR - Institut de Chimie Moléculaire de Reims
  • IFTH Activateurs de projets, Troyes

Scientific platforms:

Financial ressources

  • ASPIC : Analysis of the cell therapy product implantation site in a model of critical ischemia of the lower limbs (2015-2018) - Essaimage
  • BALI - Bone marrow Autograft in Limb Ischemia (2008) - PHRC
  • CIFRE (2009-2011) - Industriel
  • Study of the role of microparticles and tissue factor in the pro-thrombotic phenotype and thromboembolic complications in children with acute lymphoblastic leukemias (2013-2016) - AOL
  • Study of the effect of bone tissue on thrombin generation (2012-2013) - AOL
  • Direct and / or paracrine role of mesenchymal cells (MSCs) in postischemic angiogenesis (2014) - Projet Incitatif Amont