Transversal axis "Quality of Life, Rehabilitation, Environment (QuaVRE)"

Coordinators: V.BACH (UPJV) and D.JOLLY (URCA)

Participating Teams: EA 4285 UMI 01, EA 3797, EA 3300, EA6291

To cope with stressors or stressful situations, the fit individual must develop a physiological, behavioral and / or strategic adapted response . This response aims to adapt the individual to the new conditions he (or she) faces, adaptation necessary for life. This nonspecific response involves, in particular, hormonal, cardiovascular, visceral, muscular reactions, involving tissues and organs under the control of the autonomic nervous system and, of course, psychological reactions such as representations, situational assessments, coping strategies and modes of adjustment (adaptation vs pathology).
Lacking appropriate response, the individual becomes frail and develops adaptation disorders which may be transient or permanent, resulting in a degradation of the quality of life, conditions which themselves reinforce the stress. Death may be the ultimate outcome of the exhaustion phase of the general adaptation syndrome, established by the individual to respond to stress. The distinction between this stress, termed pathological stress and normal stress, which has a stimulating effect, therefore depends on the efficiency of the adaptation phase.
The efficiency of the response may be poor or insufficient if stress is excessive (because of its intensity, its duration or repetition) and / or the response of the individual is reduced by an alteration of its physiological or cognitive capabilities. The sensitivity of the individual is also increased when he is already exposed to other stressors, mobilizing its defence capabilities. Disability, diseases, frailty associated with childhood or old age may thus be regarded as stressors.

The central theme of this axis concerns "the impact of stressful situations on the individual: physiological, psychological, and clinical implications in terms of quality of life."
The working hypothesis is that the effectiveness of the adaptive response to stressful situations, whether physiological or cognitive, is impaired in frail individuals, jeopardizing their survival, their health or quality of life.
This theme is unifiying for the teams involved in the QuaVRE axis, which all study populations described as "fragile" because of their age (newborns, children, elderly), their disease or disability (cardiorespiratory, metabolic, functional, autism, deafness, cancer, Alzheimer's disease, muscular dystrophy, etc.). The competencies grouped in this axis are complementary and focus on various aspects of physiology of vital functions (sleep, thermoregulation, cardio-respiratory system, neuromuscular system, motricity), social psychology, clinical psychology, clinical epidemiology and social public health.